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certain pathways are activated or inhibited by specific SCBs. Because of the wide array of chemical structures discovered as cannabinoid agonists, it is extremely plausible that structurally distinct ligands bind to CB1Rs in a unique means. Receptor conformations resulting within the binding of particular person ligands, or a number of, at the same time binding ligands, might dictate the type, energy and quantity of G-proteins activated from the receptor. The variety of possible cannabinoid receptor-ligand complexes, along with the numerous downstream pathways that may be differentially activated or inhibited, give enough possibility for purposeful selectivity, which indeed has become effectively recognized in cannabinoid receptor signaling (Bosier et al.
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